Adenoid cystic carcinoma of paranasal sinus - about 2 cases

Adenoid cystic carcinoma [ACC] is a fairly uncommon malignant disease that accounts for about 1.3% of all paranasal sinus cancers, and occurs most commonly in the minor salivary gl and s of the head and neck. ACC grows slowly. However, it frequently recurs and metastasizes to distant organs such as lung or bone after treatment, and the prognosis is poor. Locally advanced lesions are usually managed best by resection and postoperative radiotherapy

[Intrathoracic goiters]

True intrathoracic goitres without any connexion with the cervical gland are rare. They present as tumours of the upper mediastinum. Mediastinal CT scan is the investigation of choice. Treatment is exclusively surgical because of the risk of mediastinal compression. In this report we describe a case of goitre which was diagnosed fortuitously in a 45 years old patient. Treatment was surgical with a left anterolateral thoracotomy

Lingual thyroid: about two case

Lingual thyroid is an uncommon developmental abnormality which results from the failure of the thyroid gland to descend from the foramen coecum to its prelaryngeal site. Diagnosis is assessed by the clinical picture and thyroid uptake scintiscans. Treatment is essentially medical although surgery is indicated when compression occurs. In this report, we describe two cases of lingual thyroid which were diagnosed because of an obstructive oropharyngeal syndrome in one case and hypothyroidism in the other one

[Nonsyndromic deafness-the segregation analysis]

The hearing loss is a problems of public health which can be described as major from the economic and human point of view, since 1 child over 1000 has at the birth a severe or profound deafness. This deafness has a prevalence of 1 per 10 in certain Tunisian geographical isolates. Our work concerned 33 patients with nonsyndromic sensorineural deafness who are regarded as probands and are recruited in service ORL of the Hospital La Rabta of Tunis. For each patient, a family investigation was carried out in residence and complete pedigrees were established. In addition, we selected a sample of 320 unaffected subjects for whom we established pedigrees in order to compare their inbreeding coefficient with that of the patients The samples of this study are orginated from the governorate of Bizerte The segregation analysis by the method of the maximum likelihood applied to the sample of deafs allowed to estimate the segregation frequency by taking account of various modes of selection in the sibships. The results obtained are compatible with autosomic recessive model with complete penetrance of the gene. The recessive hypothesis is strenghthened by the increase in the inbreeding coefficient of the probands compared to that of the controls